Nursing turnovers may cause a serious setback to the quality of health delivery system. In addition, this turnover increases direct and indirect labor costs. This study examined the influence of job demand, job control, and social support on clinical nurses' turnover intention based on the job strain model. In total, 373 hospital clinical nurses in northern, central, and southern Taiwan were surveyed. The results show that nurses in high job demand and low-control work situations reveal the highest turnover intention. Job-related social support may decrease this turnover rate.