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| Title: | Taiwanin E Induces Cell Cycle Arrest and Apoptosis in Arecoline/4-NQO-Induced Oral Cancer Cells Through Modulation of the ERK Signaling Pathway |
| Authors: | 王士豪;Wang, Shih Hao;Wu, Hsi-Chin;Wu, Hsi-Chin;Farheen, Khan;Badrealam, Khan Farheen;郭悅雄;Kuo, Yueh-Hsiung;Cha, Yun-Peng;Chao, Yun-Peng;Hs, Hsi-Hsien;Hsu, Hsi-Hsien;Bau, Da-Tian;Bau, Da-Tian;Padma, Vijaya;Viswanadha, Vijaya Padma;陳宜惠;CHEN, YI-HUI;Lio, Pei-Jei;Lio, Pei-Jei;黃志揚;Huang, Chih-Yang |
| Contributors: | 醫學檢驗暨生物技術學系 |
| Keywords: | Taiwanin E;apoptosis;cell cycle arrest;oral cancer;therapeutics. |
| Date: | 2019-12 |
| Issue Date: | 2020-09-04 05:58:05 (UTC+0) |
| Publisher: | 亞洲大學 |
| Abstract: | Taiwanin E is a bioactive compound extracted from Taiwania cryptomerioides Hayata. In this research endeavor, we studied the anti-cancer effect of Taiwanin E against arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cancer cells (OSCC), and elucidated the underlying intricacies. OSCC were treated with Taiwanin E and analyzed through MTT assay, Flow cytometry, TUNEL assay, and Western blotting for their efficacy against OSCC. Interestingly, it was found that Taiwanin E significantly attenuated the cell viability of oral cancer cells (T28); however, no significant cytotoxic effects were found for normal oral cells (N28). Further, Flow cytometry analysis showed that Taiwanin E induced G1cell cycle arrest in T28 oral cancer cells and Western blot analysis suggested that Taiwanin E considerably downregulated cell cycle regulatory proteins and activated p53, p21, and p27 proteins. Further, TUNEL and Western blot studies instigated that it induced cellular apoptosis and attenuated the p-PI3K/p-Akt survival mechanism in T28 oral cancer cells seemingly through modulation of the ERK signaling cascade. Collectively, the present study highlights the prospective therapeutic efficacy of Taiwanin E against arecoline and 4-nitroquinoline-1-oxide-induced oral cancer. |
| Relation: | Frontiers in Oncology |
| Appears in Collections: | [醫學檢驗暨生物技術學系] 期刊論文
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