ASIA unversity:Item 310904400/112933
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    题名: Taiwanin E Induces Cell Cycle Arrest and Apoptosis in Arecoline/4-NQO-Induced Oral Cancer Cells Through Modulation of the ERK Signaling Pathway
    作者: 王士豪;Wang, Shih Hao;Wu, Hsi-Chin;Wu, Hsi-Chin;Farheen, Khan;Badrealam, Khan Farheen;郭悅雄;Kuo, Yueh-Hsiung;Cha, Yun-Peng;Chao, Yun-Peng;Hs, Hsi-Hsien;Hsu, Hsi-Hsien;Bau, Da-Tian;Bau, Da-Tian;Padma, Vijaya;Viswanadha, Vijaya Padma;陳宜惠;CHEN, YI-HUI;Lio, Pei-Jei;Lio, Pei-Jei;黃志揚;Huang, Chih-Yang
    贡献者: 醫學檢驗暨生物技術學系
    关键词: Taiwanin E;apoptosis;cell cycle arrest;oral cancer;therapeutics.
    日期: 2019-12
    上传时间: 2020-09-04 05:58:05 (UTC+0)
    出版者: 亞洲大學
    摘要: Taiwanin E is a bioactive compound extracted from Taiwania cryptomerioides Hayata. In this research endeavor, we studied the anti-cancer effect of Taiwanin E against arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cancer cells (OSCC), and elucidated the underlying intricacies. OSCC were treated with Taiwanin E and analyzed through MTT assay, Flow cytometry, TUNEL assay, and Western blotting for their efficacy against OSCC. Interestingly, it was found that Taiwanin E significantly attenuated the cell viability of oral cancer cells (T28); however, no significant cytotoxic effects were found for normal oral cells (N28). Further, Flow cytometry analysis showed that Taiwanin E induced G1cell cycle arrest in T28 oral cancer cells and Western blot analysis suggested that Taiwanin E considerably downregulated cell cycle regulatory proteins and activated p53, p21, and p27 proteins. Further, TUNEL and Western blot studies instigated that it induced cellular apoptosis and attenuated the p-PI3K/p-Akt survival mechanism in T28 oral cancer cells seemingly through modulation of the ERK signaling cascade. Collectively, the present study highlights the prospective therapeutic efficacy of Taiwanin E against arecoline and 4-nitroquinoline-1-oxide-induced oral cancer.
    關聯: Frontiers in Oncology
    显示于类别:[醫學檢驗暨生物技術學系] 期刊論文

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