An integrative tool for gene regulatory network reconstruction based on microarray data

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 會議論文 > Item 310904400/8760

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8760

Title:	An integrative tool for gene regulatory network reconstruction based on microarray data
Authors:	Ou, J.W.;Tang, C.Y.;Hu, R.M.;Chen, R.M.;Tsai, Jeffrey J. P.
Contributors:	Department of Biotechnology
Keywords:	Bioactivity;Bioinformatics;Genes;Histology;Laws and legislation;Network components;Transcription factors;Gene expression analysis;Gene regulatory network;Gene regulatory networks;Genes expression;Microarray data;Network component analysis;Regulatory patterns;Transcriptional regulation
Date:	2009
Issue Date:	2010-04-08 11:17:48 (UTC+0)
Publisher:	Asia University
Abstract:	The transcriptional regulation of gene expression has been known to be a key mechanism in the functioning of the cell and the gene expression is influenced by the transcriptional regulatory strengths. In this paper we extend the function of a former proposed gene expression analysis tool named Gene Expression Explorer to include the gene regulatory network reconstruction based on microarray data. The regulatory strengths between transcription factors and genes are implemented by a modified network component analysis method where the genes expression relationships between genes vs. tissues and transcription factors vs. tissues are adopted to explore the regulatory strengths between genes and various transcription factors. Visualized presentation of the proposed tool clearly illustrates the regulatory patterns of transcription factors for each related gene. The biologists could benefit from using this tool to analyze the gene regulatory network based on microarray data. © 2009 IEEE.
Relation:	Proceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009:467-470
Appears in Collections:	[生物科技學系] 會議論文

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