Phenethyl Isothiocyanate Inhibits In Vivo Growth of Subcutaneous Xenograft Tumors of Human Malignant Melanoma A375.S2 Cells.

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題名:	Phenethyl Isothiocyanate Inhibits In Vivo Growth of Subcutaneous Xenograft Tumors of Human Malignant Melanoma A375.S2 Cells.
作者:	WEI-YA, NI;WEI-YA, NI;HSU-FENG, LU;HSU-FENG, LU;HSU, SHU-CHUN;HSU, SHU-CHUN;HSIA, YU-PING;HSIAO, YU-PING;KUO-CHING, LI;LIU, KUO-CHING;LIU, JIA-YOU;LIU, JIA-YOU;BIN-CHUAN, JI;BIN-CHUAN, JI;SHU-CHING, HS;HSUEH, SHU-CHING;鍾景光*
貢獻者:	生物科技學系
關鍵詞:	A375.S2 melanoma cells;PEITC;in vivo;nude mice
日期:	2014-09
上傳時間:	2014-11-07 06:52:01 (UTC+0)
摘要:	Numerous studies have shown that phenethyl isothiocyanate (PEITC) induces apoptosis of different types of human cancer cell lines, however, there are no reports showing that PEITC inhibits tumor growth in a xenograft model of melanoma in nude mice. We investigated effects of PEITC on the growth of xenografted A375.S2 cell tumors in nude BALB/c mice. A375.S2 cancer cells were inoculated subcutaneously into the lower flanks of mice. Seven days post-inoculation, mice having one palpable tumor were randomly divided into three groups and injected intraperitoneally with PEITC (0, 20 and 40 mg/kg). PEITC reduced tumor weight but total body weight was unaffected. These in vivo results provide support for further investigations to determine the potential use of PEITC as an anticancer drug. Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
關聯:	IN VIVO;28(5):891-4.
顯示於類別:	[生物科技學系] 期刊論文

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