Phenethyl Isothiocyanate Inhibits In Vivo Growth of Subcutaneous Xenograft Tumors of Human Malignant Melanoma A375.S2 Cells.

ASIAIR > College of Medical and Health Science > Department of Biotechnology > Journal Article > Item 310904400/86927

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/86927

Title:	Phenethyl Isothiocyanate Inhibits In Vivo Growth of Subcutaneous Xenograft Tumors of Human Malignant Melanoma A375.S2 Cells.
Authors:	WEI-YA, NI;WEI-YA, NI;HSU-FENG, LU;HSU-FENG, LU;HSU, SHU-CHUN;HSU, SHU-CHUN;HSIA, YU-PING;HSIAO, YU-PING;KUO-CHING, LI;LIU, KUO-CHING;LIU, JIA-YOU;LIU, JIA-YOU;BIN-CHUAN, JI;BIN-CHUAN, JI;SHU-CHING, HS;HSUEH, SHU-CHING;鍾景光*
Contributors:	生物科技學系
Keywords:	A375.S2 melanoma cells;PEITC;in vivo;nude mice
Date:	2014-09
Issue Date:	2014-11-07 06:52:01 (UTC+0)
Abstract:	Numerous studies have shown that phenethyl isothiocyanate (PEITC) induces apoptosis of different types of human cancer cell lines, however, there are no reports showing that PEITC inhibits tumor growth in a xenograft model of melanoma in nude mice. We investigated effects of PEITC on the growth of xenografted A375.S2 cell tumors in nude BALB/c mice. A375.S2 cancer cells were inoculated subcutaneously into the lower flanks of mice. Seven days post-inoculation, mice having one palpable tumor were randomly divided into three groups and injected intraperitoneally with PEITC (0, 20 and 40 mg/kg). PEITC reduced tumor weight but total body weight was unaffected. These in vivo results provide support for further investigations to determine the potential use of PEITC as an anticancer drug. Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
Relation:	IN VIVO;28(5):891-4.
Appears in Collections:	[Department of Biotechnology] Journal Article

Files in This Item:

There are no files associated with this item.

Loading...