Lung Cancer Susceptibility and Genetic Polymorphisms of Exo1 Gene in Taiwan

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題名:	Lung Cancer Susceptibility and Genetic Polymorphisms of Exo1 Gene in Taiwan
作者:	Hsu, NY (Hsu, Nan-Yung);Wang, HC (Wang, Hwei-Chung);Wang, CH (Wang, Chung-Hsing);Chiu, CF (Chiu, Chang-Fang);Tseng, HC (Tseng, Hsien-Chang);Liang, SY (Liang, Shiu-Yun);Tsai, CW (Tsai, Chia-Wen);Lin, CC (Lin, Cheng-Chieh);Bau, DT (Bau, Da-Tian)
貢獻者:	Department of Healthcare Administration
關鍵詞:	Exo1;polymorphism;lung cancer;carcinogenesis;SINGLE NUCLEOTIDE POLYMORPHISM;DNA MISMATCH REPAIR;NONPOLYPOSIS COLORECTAL-CANCER;SACCHAROMYCES-CEREVISIAE EXO1;HUMAN EXONUCLEASE-I;ORAL-CANCER;XRCC4 GENE;IDENTIFICATION;POPULATION;MUTATIONS
日期:	2009-02
上傳時間:	2010-03-26 02:52:44 (UTC+0)
出版者:	Asia University
摘要:	Aim: To evaluate the association between the polymorphisms of the Exo1 gene and the risk of lung cancer in central Taiwan. Patients and Methods: In this hospital-based study, the association of Exo1 A-1419G (rs3754093), C-908G (rs10802996), A238G (rs1776177), C498T (rs1635517), K589E (rs1047840), G670E (rs1776148), C723R (rs1635498), L757P (rs9350) and C3114T (rs851797) polymorphisms with lung cancer risk in a central Taiwanese population was investigated. In total, 358 patients with lung cancer and 358 age- and gender-matched healthy controls recruited front the China Medical Hospital in central Taiwan were genotyped. Results: A significantly, different distribution was found in the frequency of the Exo1 K589E genotype, but not the other genotypes, between the lung cancer and control groups. The A allele Exo1 K589E conferred a significantly (p=0.0097) increased risk of lung cancer. As for the rest of the polymorphisms, there was no difference in distribution between the lung cancer and control groups. Gene environment interactions with smoking were significant for Exo1 K589E polymorphism. The Exo1 K589E AG and AA genotype in association with smoking conferred an increased risk of 1.7208 (95% confidence interval=1.2188-2.4295) for lung cancer. Conclusion: Our results provide the first evidence that the A allele of Exo1 K589E may be associated with the development of lung cancer and may be a novel useful marker for primary prevention and anticancer intervention.
關聯:	ANTICANCER RESEARCH 29 (2): 725-730
顯示於類別:	[健康產業管理學系] 期刊論文

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