Treatment with Taurine Attenuates Hepatic Apoptosis in NZB/W F1 Mice Fed with a High-Cholesterol Diet

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/8432

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8432

Title:	Treatment with Taurine Attenuates Hepatic Apoptosis in NZB/W F1 Mice Fed with a High-Cholesterol Diet
Authors:	Hsu, TC;Hsu, Tsai-Ching;Chiang, SY;Chiang, Szu-Yi;Wu, JH;Wu, Jen-Huang;Tsai, CC;Tsai, Chun-Chou;Huang, CY;Huang, Chih-Yang;Chen, YC;Chen, Yi-Chen;Tzang, BS;Tzang, Bor-Show
Contributors:	保健系
Keywords:	Apoptosis;cholesterol;liver;systemic lupus erythematosus (SLE);taurine;SYSTEMIC-LUPUS-ERYTHEMATOSUS;TRANSGLUTAMINASE INHIBITOR CYSTAMINE;ACID-INDUCED APOPTOSIS;OXIDATIVE STRESS;CYCLOSPORINE-A;RAT-LIVER;ACTIVATION;CELLS;INFLAMMATION;MECHANISM
Date:	2008-10
Issue Date:	2010-03-26 02:46:40 (UTC+0)
Publisher:	Asia University
Abstract:	Cholesterol-rich diets are known to cause hepatic apoptosis, which has been associated with the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanisms and treatments for hepatic apoptosis in SLE are poorly understood. To clarify the effects of taurine on hepatic apoptosis in SLE, NZB/W F1 mice received control, cholesterol, and cholesterol/taurine diets. Significant reductions of caspase-3 activity, TUNEL-positive cells, and Fas- and mitochondrial- dependent apoptosis were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. Moreover, significant increases of phosphorylated AKT, NF-kappa B (p65), and ERK1/2 proteins were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. In contrast, a significant reduction of phosphorylated p38 protein was observed in the cholesterol/taurine group. These experimental results demonstrated positive effects of taurine against hepatic apoptosis in NZB/W F1 mice fed a high-cholesterol diet and suggested the therapeutic potential of taurine in SLE.
Relation:	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56(20):9685-9691.
Appears in Collections:	[食品營養與保健生技學系] 期刊論文

Files in This Item:

File	Description	Size	Format
377.docx		0Kb	Unknown	464	View/Open
377.doc		37Kb	Microsoft Word	686	View/Open

Loading...