ASIA unversity:Item 310904400/8432
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    题名: Treatment with Taurine Attenuates Hepatic Apoptosis in NZB/W F1 Mice Fed with a High-Cholesterol Diet
    作者: Hsu, TC;Hsu, Tsai-Ching;Chiang, SY;Chiang, Szu-Yi;Wu, JH;Wu, Jen-Huang;Tsai, CC;Tsai, Chun-Chou;Huang, CY;Huang, Chih-Yang;Chen, YC;Chen, Yi-Chen;Tzang, BS;Tzang, Bor-Show
    贡献者: 保健系
    关键词: Apoptosis;cholesterol;liver;systemic lupus erythematosus (SLE);taurine;SYSTEMIC-LUPUS-ERYTHEMATOSUS;TRANSGLUTAMINASE INHIBITOR CYSTAMINE;ACID-INDUCED APOPTOSIS;OXIDATIVE STRESS;CYCLOSPORINE-A;RAT-LIVER;ACTIVATION;CELLS;INFLAMMATION;MECHANISM
    日期: 2008-10
    上传时间: 2010-03-26 02:46:40 (UTC+0)
    出版者: Asia University
    摘要: Cholesterol-rich diets are known to cause hepatic apoptosis, which has been associated with the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanisms and treatments for hepatic apoptosis in SLE are poorly understood. To clarify the effects of taurine on hepatic apoptosis in SLE, NZB/W F1 mice received control, cholesterol, and cholesterol/taurine diets. Significant reductions of caspase-3 activity, TUNEL-positive cells, and Fas- and mitochondrial- dependent apoptosis were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. Moreover, significant increases of phosphorylated AKT, NF-kappa B (p65), and ERK1/2 proteins were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. In contrast, a significant reduction of phosphorylated p38 protein was observed in the cholesterol/taurine group. These experimental results demonstrated positive effects of taurine against hepatic apoptosis in NZB/W F1 mice fed a high-cholesterol diet and suggested the therapeutic potential of taurine in SLE.
    關聯: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56(20):9685-9691.
    显示于类别:[食品營養與保健生技學系] 期刊論文

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