ZAK negatively regulates RhoGDI beta-induced Rac1-mediated hypertrophic growth and cell migration

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/8389

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8389

Title:	ZAK negatively regulates RhoGDI beta-induced Rac1-mediated hypertrophic growth and cell migration
Authors:	Huang, CY;Huang, Chih-Yang;Yang, LC;Yang, Li-Chiu;Liu, KY;Liu, Kuan-Yu;Chang, IC;Chang, I-Chang;Liao, PH;Liao, Pao-Hsin;Chou, JIY;Chou, Janet Ing-Yuh;Chou, MY;Chou, Ming-Yung;Lin, WW;Lin, Wei-Wen;Yang, JJ;Yang, Jaw-Ji
Contributors:	保健系
Keywords:	CARDIOMYOBLAST CELLS;GTPASES;EXPRESSION;KINASE;GDI;RAC;PATHWAYS;ADHESION;PROTEIN
Date:	2009-06
Issue Date:	2010-03-26 02:46:20 (UTC+0)
Publisher:	Asia University
Abstract:	RhoGDI beta, a Rho GDP dissociation inhibitor, induced hypertrophic growth and cell migration in a cultured cardiomyoblast cell line, H9c2. We demonstrated that RhoGDI beta plays a previously undefined role in regulating Rac1 expression through transcription to induce hypertrophic growth and cell migration and that these functions are blocked by the expression of a dominant-negative form of Rac1. We also demonstrated that knockdown of RhoGDI beta expression by RNA interference blocked RhoGDI beta-induced Rac1 expression and cell migration. We demonstrated that the co-expression of ZAK and RhoGDI beta in cells resulted in an inhibition in the activity of ZAK to induce ANF expression. Knockdown of ZAK expression in ZAK-RhoGDI beta-expressing cells by ZAK-specific RNA interference restored the activities of RhoGDI beta.
Relation:	JOURNAL OF BIOMEDICAL SCIENCE, 16:56
Appears in Collections:	[食品營養與保健生技學系] 期刊論文

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