Octreotide Therapy in Asparaginase-Associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/8319

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题名:	Octreotide Therapy in Asparaginase-Associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia
作者:	Wu, SF (Wu, Shu-Fen);Chen, AC (Chen, An-Chyi);Peng, CT (Peng, Ching-Tien);Wu, KH (Wu, Kang-Hsi)
贡献者:	Department of Biotechnology
关键词:	acute lymphoblastic leukemia;L-asparaginase;octreotide;pancreatitis；SOMATOSTATIN;TRIAL
日期:	2008-12
上传时间:	2010-03-26 02:29:47 (UTC+0)
出版者:	Asia University
摘要:	Little is known about octreotide therapy in asparaginase-associated pancreatitis (AAP) in children. Of the 59 children with acute lymphoblastic leukemia (ALL) receiving E. Coli L-asparaginase, 5 patients (8.5%) developed AAP. Octreotide was administered to four patients. Clinical and laboratory improvement were evident after octreotide therapy. There were no deaths and no severe adverse side effects were noted. No pseudocysts were detected; however, two of the four patients developed diabetes. One child without octreotide treatment developed chronic pancreatitis and pseudocyst. We conclude that octreotide therapy appears to be safe and potentially beneficial in the management of AAP in children.
關聯:	PEDIATRIC BLOOD & CANCER 51 (6): 824-825
显示于类别:	[生物科技學系] 期刊論文

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