Effects of Agaricus blazei Murill Extract on Immune Responses in Normal BALB/c Mice

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題名:	Effects of Agaricus blazei Murill Extract on Immune Responses in Normal BALB/c Mice
作者:	Tang, NY (Tang, Nou-Ying);Yang, JS (Yang, Jai-Sing);Lin, JP (Lin, Jing-Pin);Hsia, TC (Hsia, Te-Chun);Fan, MJ (Fan, Ming-Jen);Lin, JJ (Lin, Jen-Jyh);Weng, SW (Weng, Shu-Wen);Ma, YS (Ma, Yi-Shih);Lu, HF (Lu, Hsu-Feng);Shen, JJ (Shen, Jiann-Jong);Lin, JG (Lin, Jaung-Geng);Chung, JG (Chung, Jing-Gung)
貢獻者:	Department of Biotechnology
關鍵詞:	Agaricus blazei Murill extract;immune responses;YAC-1 target cells;NK cells;phagocytosis;BALB/c mice
日期:	2009-09
上傳時間:	2010-03-26 02:29:19 (UTC+0)
出版者:	Asia University
摘要:	Agaricus blazei Murill (ABM) has shown particularly, strong results in treating and preventing cancer and has also traditionally been used as a food source in Brazil. However, the exact immune responses regarding the phagocytosis of macrophage and, the activity of natural killer (NK) cells in normal mice after exposure to ABM extract was unclear. The goal of this study, was to investigate whether or not ABM extract can promote immune responses in normal BALB/c mice. BALB/c mice were treated with different doses of ABM extract for different time periods. The results indicated that ABM extract significantly promoted the proliferation of splenocytes both in vitro and in vivo. ABM extract promoted the levels of interleukein-6 (IL-6) and, interferon-gamma (IFN-gamma) but reduced the levels of IL-4 in vitro and in vivo. The percentage of macrophages with phagocytosis after ABM extract treatment increased and these effects were of dose-dependent manners, both in vitro and in vivo. YAC-1 target cells were killed by NK cells from the mice after treatment with ABM extract at 3 and 6 mg/kg/day for up to 14 days at target cell ratios of 25:1 and 50:1. Taken together, these results show that ABM extract promoted immunomodulations in normal BALB/c mice in vitro and in vivo.
關聯:	IN VIVO 23 (5): 761-766
顯示於類別:	[生物科技學系] 期刊論文

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