KEAP1 E3 Ligase-Mediated Downregulation of NF-kappa B Signaling by Targeting IKK beta

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/8205

請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/8205

題名:	KEAP1 E3 Ligase-Mediated Downregulation of NF-kappa B Signaling by Targeting IKK beta
作者:	Lee, DF (Lee, Dung-Fang);Kuo, HP (Kuo, Hsu-Ping);Liu, M (Liu, Mo);Chou, CK (Chou, Chao-Kai);Xia, WY (Xia, Weiya);Du, Y (Du, Yi);Shen, J (Shen, Jia);Chen, CT (Chen, Chun-Te);Huo, L (Huo, Longfei);Hsu, MC (Hsu, Ming-Chuan);Li, CW (Li, Chia-Wei);Ding, QQ (Ding, Qingqing);Liao, TL (Liao, Tsai-Lien);Lai, CC (Lai, Chien-Chen);Lin, AC (Lin, Ann-Chi);Chang, YH (Chang, Ya-Hui);Tsai, SF (Tsai, Shih-Feng);Li, LY (Li, Long-Yuan);Hung, MC (Hung, Mien-Chie)
貢獻者:	Department of Biotechnology
關鍵詞:	TUMOR ANGIOGENESIS;BREAST-CANCER;LUNG-CANCER;NRF2;INFLAMMATION;ACTIVATION;SUBSTRATE;PATHWAY;COMPLEX;PROTEIN
日期:	2009-10
上傳時間:	2010-03-26 02:29:01 (UTC+0)
出版者:	Asia University
摘要:	I kappa B kinase beta (IKK beta) is involved in tumor development and progression through activation of the nuclear factor (NF)-kappa B pathway. However, the molecular mechanism that regulates IKK beta degradation remains largely unknown. Here, we show that a Cullin 3 (CUL3)-based ubiquitin ligase, Kelch-like ECH-associated protein 1 (KEAP1), is responsible for IKK beta ubiquitination. Depletion of KEAP1 led to the accumulation and stabilization of IKK beta and to upregulation of NF-kappa B-derived tumor angiogenic factors. A systematic analysis of the CUL3, KEAP1, and RBX1 genomic loci revealed a high percentage of genome loss and missense mutations in human cancers that failed to facilitate IKK beta degradation. Our results suggest that the dysregulation of KEAP1-mediated IKK beta ubiquitination may contribute to tumorigenesis.
關聯:	MOLECULAR CELL 36 (1): 131-140
顯示於類別:	[生物科技學系] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
21.docx		0Kb	Unknown	886	檢視/開啟
21.doc		49Kb	Microsoft Word	541	檢視/開啟

在ASIAIR中所有的資料項目都受到原著作權保護.

資料載入中.....