Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for oral cancer

ASIAIR > College of Medical and Health Science > Journal Article > Item 310904400/6574

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6574

Title:	Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for oral cancer
Authors:	Ku Kuo-Tung;Lei Wan;Hui-Chen Peng;Ming-Hsui Tsai;Chang-Hai Tsai;Fuu-Jen Tsai
Date:	2005-05
Issue Date:	2009-12-23 06:20:40 (UTC+0)
Publisher:	Asia University
Abstract:	Oral cancer is one of the most common malignant diseases in Taiwan. The incidence of male oral cancer is 9.01 times than that of female. The formation or progression of oral cancer may be associated with a polymorphism of the vascular endothelial growth factor (VEGF) gene. The most frequently seen polymorphism is BstUI (C to T) located at the ?460th nucleotide upstream of the VEGF gene. We investigated whether this polymorphism could be a genetic marker of oral cancer. A normal control group of 230 healthy people and 137 patients with oral cancer were examined. The polymorphism was detected by polymerase chain reaction-based restriction analysis. The analysis revealed significant differences between normal individuals and patients with cancer (P<0.001). The distribution of the “TT” homozygote in the patient group was greater than that in the control group. The odds ratio per copy of the “T/C” ratio was 9.62 (95% confidence interval 5.81–15.87), which means that for a group of people with a higher T/C ratio have higher risk in getting oral cancer. There is no gender difference in this VEGF gene polymorphism. Therefore, the BstUI polymorphism of the VEGF gene is a suitable genetic marker of oral cancer.
Relation:	ORAL ONCOLOGY 41 (5): 497-502
Appears in Collections:	[College of Medical and Health Science] Journal Article

Files in This Item:

File	Size	Format
	0Kb	Unknown	626	View/Open

Loading...