Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for oral cancer

ASIA unversity > 醫學暨健康學院 > 期刊論文 > Item 310904400/6574

請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/6574

題名:	Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for oral cancer
作者:	Ku Kuo-Tung;Lei Wan;Hui-Chen Peng;Ming-Hsui Tsai;Chang-Hai Tsai;Fuu-Jen Tsai
日期:	2005-05
上傳時間:	2009-12-23 06:20:40 (UTC+0)
出版者:	Asia University
摘要:	Oral cancer is one of the most common malignant diseases in Taiwan. The incidence of male oral cancer is 9.01 times than that of female. The formation or progression of oral cancer may be associated with a polymorphism of the vascular endothelial growth factor (VEGF) gene. The most frequently seen polymorphism is BstUI (C to T) located at the ?460th nucleotide upstream of the VEGF gene. We investigated whether this polymorphism could be a genetic marker of oral cancer. A normal control group of 230 healthy people and 137 patients with oral cancer were examined. The polymorphism was detected by polymerase chain reaction-based restriction analysis. The analysis revealed significant differences between normal individuals and patients with cancer (P<0.001). The distribution of the “TT” homozygote in the patient group was greater than that in the control group. The odds ratio per copy of the “T/C” ratio was 9.62 (95% confidence interval 5.81–15.87), which means that for a group of people with a higher T/C ratio have higher risk in getting oral cancer. There is no gender difference in this VEGF gene polymorphism. Therefore, the BstUI polymorphism of the VEGF gene is a suitable genetic marker of oral cancer.
關聯:	ORAL ONCOLOGY 41 (5): 497-502
顯示於類別:	[醫學暨健康學院] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
	0Kb	Unknown	626	檢視/開啟

在ASIAIR中所有的資料項目都受到原著作權保護.

資料載入中.....