A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients

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Title:	A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients
Authors:	Y-J Lin;Lei Wan;JJ-C Sheu;C-M Huang;C-W Lin;Y-C Lan;C-H Lai;C-H Hung;Y Tsai;C-H Tsai;T-H Lin;C-P Chen;F-J Tsai
Keywords:	interleukin-18;single nucleotide polymorphism;systemic lupus erythematosus
Date:	2008
Issue Date:	2009-11-30 07:57:55 (UTC+0)
Publisher:	Asia University
Abstract:	Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune diseases and various cancers and infectious diseases. An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Taiwanese SLE patients and a healthy control group. Our results indicate (1) a significantly higher A allele frequency in SLE patients (P = 0.003; OR = 1.97; 95% CI = 1.26?3.08) and (2) a significantly higher A allele frequency in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% CI = 0.95?54.28). Our results suggest that the A/C polymorphism contributes to SLE pathogenesis.
Relation:	LUPUS 17 (2): 124-127
Appears in Collections:	[Department of Biotechnology] Journal Article

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