The pace of upgrade, elimination, and replacement of information technology, products, and skills is accelerating over time. Traditional educational practice is unable to satisfy the demands of enterprises and workers. Current skills will be eliminated every three to five years, so workers must learn constantly. Similarly, educators must continuously educate their employees, to offer their customers satisfactory service in an ever-changing business environment. Entering the era of the knowledge economy, learners will require a wide variety of learning styles in order to enhance their abilities and competitiveness. Many forward-looking enterprises and knowledge workers will learn new alternatives. The concept of problem-based learning (PBL) was first put forth in 1960 and is not a new idea in the educational field. Initially it was applied in medical education, but is now used in engineering and math. Recently it has been used in general education settings. This research begins with an investigation of the basic concepts of e-learning and problem-based learning. An e-learning environment is analyzed in order to explore how teaching and learning in problem-based learning is affected by the high speed of e-learning. If learners become the focus of the process and learner problems the heart of it, then, based on the characteristics of the learners and various environmental factors, implementation of problem-based web-based learning will facilitate learner attainment of goals. Increasing learning effectiveness is necessary to attain the goal of strengthening learner motivation, independent learning, and lifelong learning.