"Cell motility involves metastasis suppressors and
other regulators that play an important role in tumor invasion
and metastasis. Phenethyl isothiocyanate (PEITC), found in
dietary cruciferous vegetables, has been found to exhibit
antitumor properties and therefore is of special interest for the
development of chemopreventive and chemotherapeutic agent
for human cancers. Here, we report that in addition to its
function as an anticancer agent, and PEITC can inhibit
migration and invasion through the extracellular signalregulated kinases 1/2 (ERK1/2), protein kinase C (PKC) and
nuclear factor-kappaB (NF-κB) signaling pathways in human
gastric cells. The results from wound healing and Boyden
chamber assays (migration and invasion) assay indicated that
PEITC exhibited an inhibitory effect on the migration and
invasion of AGS cells. Results from Western blotting
examination demonstrated that PEITC exerted an inhibitory
effect on the ERK1/2, mitogen-activated protein kinase kinase 7
(MKK7), MAP kinase kinase kinase 3 (MEKK3), son of
sevenless 1 (SOS1), PKC, Ras homolog gene family, member A
(Rho A) and urokinase-type plasminogen activator (uPA),"
