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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16621


    Title: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways
    Authors: 鍾景光;Chung, Jing-Gung
    Contributors: 生物科技學系
    Keywords: "Phenethyl isothiocyanate;migration;invasion;human gastric cancer AGS cells."
    Date: 2011-05
    Issue Date: 2012-11-23 09:15:11 (UTC+0)
    Abstract: "Cell motility involves metastasis suppressors and
    other regulators that play an important role in tumor invasion
    and metastasis. Phenethyl isothiocyanate (PEITC), found in
    dietary cruciferous vegetables, has been found to exhibit
    antitumor properties and therefore is of special interest for the
    development of chemopreventive and chemotherapeutic agent
    for human cancers. Here, we report that in addition to its
    function as an anticancer agent, and PEITC can inhibit
    migration and invasion through the extracellular signalregulated kinases 1/2 (ERK1/2), protein kinase C (PKC) and
    nuclear factor-kappaB (NF-κB) signaling pathways in human
    gastric cells. The results from wound healing and Boyden
    chamber assays (migration and invasion) assay indicated that
    PEITC exhibited an inhibitory effect on the migration and
    invasion of AGS cells. Results from Western blotting
    examination demonstrated that PEITC exerted an inhibitory
    effect on the ERK1/2, mitogen-activated protein kinase kinase 7
    (MKK7), MAP kinase kinase kinase 3 (MEKK3), son of
    sevenless 1 (SOS1), PKC, Ras homolog gene family, member A
    (Rho A) and urokinase-type plasminogen activator (uPA),"
    Relation: HUMAN & EXPERIMENTAL TOXICOLOGY
    Appears in Collections:[Department of Biotechnology] Journal Article

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