Design and assessment of a fast algorithm for identifying specific probes for human and mouse genes

ASIA unversity > 資訊學院 > 生物資訊與醫學工程學系 > 期刊論文 > Item 310904400/16536

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題名:	Design and assessment of a fast algorithm for identifying specific probes for human and mouse genes
作者:	張培均;Chang, Pei-Chun
貢獻者:	生物與醫學資訊學系
日期:	2003
上傳時間:	2012-11-23 09:14:20 (UTC+0)
摘要:	"Motivation: Mammalian genomes are highly complex. To identify the unique sequences of each gene in a mammalian gene database containing tens of thousands of DNA sequences is a computation intensive task. With the advent of parallel genetic analysis methods such as microarrays and the availability of more and more whole genome sequences of organisms, an algorithm allowing speedy identiﬁcation of the unique gene probes for functional studies of individual genes will be a very useful tool. Results: We have developed a fast algorithm as well as a software program based on the algorithm for identifying gene speciﬁc probes of complex organisms. The algorithm was applied to the assemblies of gene sequences and was highly efﬁcient for large databases such as the TIGR human THC and mouse TC databases. The results were assessed with the BLAST sequence alignment software. Two probe data sets have been compiled to contain speciﬁc probes for around 100 000 putative human gene transcripts and 70 000 putative mouse gene transcripts. Availability: The gene speciﬁc probes for the putative human and mouse genes referenced in the TIGR gene indices are available at: ftp://genestamp.ibms.sinica.edu. tw/pub/SpeciﬁcP/ The software program and the source codes are available upon request. Contact: [email protected]"
關聯:	BIOINFORMATICS
顯示於類別:	[生物資訊與醫學工程學系 ] 期刊論文

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