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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16536


    Title: Design and assessment of a fast algorithm for identifying specific probes for human and mouse genes
    Authors: 張培均;Chang, Pei-Chun
    Contributors: 生物與醫學資訊學系
    Date: 2003
    Issue Date: 2012-11-23 09:14:20 (UTC+0)
    Abstract: "Motivation: Mammalian genomes are highly complex.
    To identify the unique sequences of each gene in a
    mammalian gene database containing tens of thousands
    of DNA sequences is a computation intensive task. With
    the advent of parallel genetic analysis methods such
    as microarrays and the availability of more and more
    whole genome sequences of organisms, an algorithm
    allowing speedy identification of the unique gene probes
    for functional studies of individual genes will be a very
    useful tool.
    Results: We have developed a fast algorithm as well as
    a software program based on the algorithm for identifying
    gene specific probes of complex organisms. The algorithm
    was applied to the assemblies of gene sequences and
    was highly efficient for large databases such as the TIGR
    human THC and mouse TC databases. The results were
    assessed with the BLAST sequence alignment software.
    Two probe data sets have been compiled to contain
    specific probes for around 100 000 putative human gene
    transcripts and 70 000 putative mouse gene transcripts.
    Availability: The gene specific probes for the putative
    human and mouse genes referenced in the TIGR gene
    indices are available at: ftp://genestamp.ibms.sinica.edu.
    tw/pub/SpecificP/ The software program and the source
    codes are available upon request.
    Contact: [email protected]"
    Relation: BIOINFORMATICS
    Appears in Collections:[Department of Biomedical informatics  ] Journal Article

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