"The purpose of this study was to estimate the role
of the SLC34A2 gene in breast cancer. A total of 146 samples
were collected from breast cancer tissues and their adjacent
normal breast tissues. Reverse transcription and real-time
polymerase chain reaction were used to estimate gene
expression levels. There was a significantly increased gene
expression of SLC34A2 (normal tissues: 6.71±0.77; tumour
tissues: 10.29±0.80) among breast cancer tissues compared
with normal tissues. However, there was no significant
association between overall survival and the gene expression
level of SLC34A2. Moreover, a significant overexpression of
CA125 (normal tissues: 7.26±0.62; tumour tissues:
10.51±0.58) in breast cancer tissues and a significant
correlation between SLC34A2 and CA125 gene expressions
were found. Our results suggested SLC34A2 to be involved
in the development of breast cancer; this gene may therefore
be a novel marker for the detection of breast cancer and act
as a target gene in therapeutic strategies."
