SLC34A2 as a novel marker for diagnosis and targeted therapy of breast cancer

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/16501

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题名:	SLC34A2 as a novel marker for diagnosis and targeted therapy of breast cancer
作者:	鍾景光;Chung, Jing-Gung
贡献者:	生物科技學系
关键词:	Type II sodium-dependent phosphate transporter;SLC34A2;diagnosis;therapy;breast cancer.
日期:	2010-10
上传时间:	2012-11-23 09:13:55 (UTC+0)
摘要:	"The purpose of this study was to estimate the role of the SLC34A2 gene in breast cancer. A total of 146 samples were collected from breast cancer tissues and their adjacent normal breast tissues. Reverse transcription and real-time polymerase chain reaction were used to estimate gene expression levels. There was a significantly increased gene expression of SLC34A2 (normal tissues: 6.71±0.77; tumour tissues: 10.29±0.80) among breast cancer tissues compared with normal tissues. However, there was no significant association between overall survival and the gene expression level of SLC34A2. Moreover, a significant overexpression of CA125 (normal tissues: 7.26±0.62; tumour tissues: 10.51±0.58) in breast cancer tissues and a significant correlation between SLC34A2 and CA125 gene expressions were found. Our results suggested SLC34A2 to be involved in the development of breast cancer; this gene may therefore be a novel marker for the detection of breast cancer and act as a target gene in therapeutic strategies."
關聯:	ANTICANCER RESEARCH
显示于类别:	[生物科技學系] 期刊論文

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