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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16217


    Title: Anti-Inflammatory Effects of Probiotic Lactobacillus paracasi on Ventricles of BALB/C Mice Treated with Ovalbumin
    Authors: 黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Keywords: allergy, inflammation, apoptosis, lactic acid bacteria, ovalbumin
    Date: 2012
    Issue Date: 2012-11-23 09:10:04 (UTC+0)
    Abstract: "Lactic acid bacteria (LAB) are microorganisms that benefit animals with allergic diseases and
    intestinal disorders such as inflammatory bowel disease. We propose that LAB can prevent cardiomyocytes
    inflammation and apoptosis in BALB/c mice using an ovalbumin (OVA)-induced allergy. Thirty-nine
    male BALB/c mice were divided into five groups: normal control, allergy control and three allergy
    groups each treated with Kefir I (Kefir I), Kefir II (Kefir II) or GM080 products (GM080). The
    myocardial architecture and apoptotic molecules in the excised left ventricle from these mice were
    investigated and post-treatment effects were evaluated. The inflammatory pathway, including toll-like
    receptor 4 (TLR4), phospholate-Jun-N-terminal kinase (p-JNK), JNK1/2 and tumor necrosis factoralpha (TNF-α) and the mitochondria-dependent apoptosis phospholate-p38 (p-p38), Bcl-2 associated
    agonist of cell death (Bad), Bcl-2 associated X (Bax) and activated caspase 3, were found to be significantly increased in the hearts of allergy mice. The expression of phospholate-nuclear factor-κB (p-NFκB),
    TNF-α, p-p38 and Bad protein products were reduced or retarded in the Kefir I- or II-treated allergy
    group. The GM080-treated allergy group exhibited significantly lower p-JNK, JNK1/2, phospholateIkappa B (p-IκB), Bax and Bad protein products than the Kefir I and Kefir II allergy groups. These
    results indicate that LAB can reduce inflammation and prevent apoptosis of cardiomyocytes in the heart
    of OVA-induced allergy mice."
    Relation: CHINESE JOURNAL OF PHYSIOLOGY
    Appears in Collections:[生物科技學系] 期刊論文

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