ASIA unversity:Item 310904400/16217
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    题名: Anti-Inflammatory Effects of Probiotic Lactobacillus paracasi on Ventricles of BALB/C Mice Treated with Ovalbumin
    作者: 黃志揚;HUANG, CHIH-YANG
    贡献者: 生物科技學系
    关键词: allergy, inflammation, apoptosis, lactic acid bacteria, ovalbumin
    日期: 2012
    上传时间: 2012-11-23 09:10:04 (UTC+0)
    摘要: "Lactic acid bacteria (LAB) are microorganisms that benefit animals with allergic diseases and
    intestinal disorders such as inflammatory bowel disease. We propose that LAB can prevent cardiomyocytes
    inflammation and apoptosis in BALB/c mice using an ovalbumin (OVA)-induced allergy. Thirty-nine
    male BALB/c mice were divided into five groups: normal control, allergy control and three allergy
    groups each treated with Kefir I (Kefir I), Kefir II (Kefir II) or GM080 products (GM080). The
    myocardial architecture and apoptotic molecules in the excised left ventricle from these mice were
    investigated and post-treatment effects were evaluated. The inflammatory pathway, including toll-like
    receptor 4 (TLR4), phospholate-Jun-N-terminal kinase (p-JNK), JNK1/2 and tumor necrosis factoralpha (TNF-α) and the mitochondria-dependent apoptosis phospholate-p38 (p-p38), Bcl-2 associated
    agonist of cell death (Bad), Bcl-2 associated X (Bax) and activated caspase 3, were found to be significantly increased in the hearts of allergy mice. The expression of phospholate-nuclear factor-κB (p-NFκB),
    TNF-α, p-p38 and Bad protein products were reduced or retarded in the Kefir I- or II-treated allergy
    group. The GM080-treated allergy group exhibited significantly lower p-JNK, JNK1/2, phospholateIkappa B (p-IκB), Bax and Bad protein products than the Kefir I and Kefir II allergy groups. These
    results indicate that LAB can reduce inflammation and prevent apoptosis of cardiomyocytes in the heart
    of OVA-induced allergy mice."
    關聯: CHINESE JOURNAL OF PHYSIOLOGY
    显示于类别:[生物科技學系] 期刊論文

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