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| Title: | Effects of Magnesium Sulfate on Dynamic Changes in Blood Glucose Levels and Glucose Transporter-3 Expression in the Striatum during Short-term Forced Swimming in Gerbi |
| Authors: | 陳怡如;Chen, I-Ju;鄭秀敏;Cheng, Shiu-Min |
| Contributors: | 心理學系 |
| Keywords: | Forced swimming;Glucose transporter;Magnesium;Striatum |
| Date: | 2010-02 |
| Issue Date: | 2012-11-23 07:03:56 (UTC+0) |
| Abstract: | In a previous study, we reported that when gerbils were subjected to a period of forced swimming, glucose levels and
magnesium levels in the plasma became elevated. In addition, a pretreatment with magnesium sulfate increased the
expression of glucose transporter-3 (GLUT-3) in the cortex. The goal of the present study was to evaluate dynamic
changes in blood glucose, lactate and magnesium levels in gerbils that had been subjected to short-term forced
swimming using an auto-blood-sampling system. A second goal was to investigation the effects of forced swimming
and magnesium sulfate on GLUT-3 expression, glucose and magnesium levels in the striatum, which is involved in
energy delivery and motor function. Data collection involved the use of a microdialysis analyzer, a flame atomic
absorption spectrometer and western blotting assays to detect glucose, lactate, magnesium and GLUT-3 levels,
respectively. Gerbils were subjected to a blood sampling assay and pretreated with saline (n=6) or magnesium sulfate
(n=6, 90 mg·kg-1, ip) 30 min before the period of forced swimming. Whole blood glucose, lactate, and magnesium
levels increased to 175% and 235%, 305% and 190%, and 102% and 128% of basal levels during swimming in both the
control and magnesium sulfate-treated groups (p<0.05). The glucose and magnesium levels during swimming were
60% and 26% greater in the magnesium sulfate-treated group (p<0.05), respectively, whereas the lactate levels were
attenuated at 115% (p<0.05). Another group of gerbils was subjected to a brain sampling assay. The gerbils were
separated into four groups (n=4, each group): control group (C group) pretreated only with saline; magnesium sulfate
group (Mg group) pretreated only with magnesium sulfate; saline control and forced swimming group (C+S group)
pretreated with saline 15 min prior to the forced swimming period then rested for 30 min; the magnesium sulfate plus
the forced swimming group (Mg+S group) was pretreated with magnesium sulfate 15 min prior to the forced swimming
period then rested for 30 min. The results indicated that GLUT-3 and magnesium levels were slightly, but not
significantly higher in the Mg group, the C+S group and the Mg+S group. These data suggest that magnesium
increased whole blood glucose and magnesium levels during forced swimming; however, the effects of magnesium and
swimming on GLUT-3 protein expression varied in different regions of the brain. |
| Relation: | international journal of sport and exercise science,, 2(1):19-26 |
| Appears in Collections: | [心理學系] 期刊論文
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