Effects of Magnesium Sulfate on Dynamic Changes in Blood Glucose Levels and Glucose Transporter-3 Expression in the Striatum during Short-term Forced Swimming in Gerbi

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Title:	Effects of Magnesium Sulfate on Dynamic Changes in Blood Glucose Levels and Glucose Transporter-3 Expression in the Striatum during Short-term Forced Swimming in Gerbi
Authors:	陳怡如;Chen, I-Ju;鄭秀敏;Cheng, Shiu-Min
Contributors:	心理學系
Keywords:	Forced swimming;Glucose transporter;Magnesium;Striatum
Date:	2010-02
Issue Date:	2012-11-23 07:03:56 (UTC+0)
Abstract:	In a previous study, we reported that when gerbils were subjected to a period of forced swimming, glucose levels and magnesium levels in the plasma became elevated. In addition, a pretreatment with magnesium sulfate increased the expression of glucose transporter-3 (GLUT-3) in the cortex. The goal of the present study was to evaluate dynamic changes in blood glucose, lactate and magnesium levels in gerbils that had been subjected to short-term forced swimming using an auto-blood-sampling system. A second goal was to investigation the effects of forced swimming and magnesium sulfate on GLUT-3 expression, glucose and magnesium levels in the striatum, which is involved in energy delivery and motor function. Data collection involved the use of a microdialysis analyzer, a flame atomic absorption spectrometer and western blotting assays to detect glucose, lactate, magnesium and GLUT-3 levels, respectively. Gerbils were subjected to a blood sampling assay and pretreated with saline (n=6) or magnesium sulfate (n=6, 90 mg·kg-1, ip) 30 min before the period of forced swimming. Whole blood glucose, lactate, and magnesium levels increased to 175% and 235%, 305% and 190%, and 102% and 128% of basal levels during swimming in both the control and magnesium sulfate-treated groups (p<0.05). The glucose and magnesium levels during swimming were 60% and 26% greater in the magnesium sulfate-treated group (p<0.05), respectively, whereas the lactate levels were attenuated at 115% (p<0.05). Another group of gerbils was subjected to a brain sampling assay. The gerbils were separated into four groups (n=4, each group): control group (C group) pretreated only with saline; magnesium sulfate group (Mg group) pretreated only with magnesium sulfate; saline control and forced swimming group (C+S group) pretreated with saline 15 min prior to the forced swimming period then rested for 30 min; the magnesium sulfate plus the forced swimming group (Mg+S group) was pretreated with magnesium sulfate 15 min prior to the forced swimming period then rested for 30 min. The results indicated that GLUT-3 and magnesium levels were slightly, but not significantly higher in the Mg group, the C+S group and the Mg+S group. These data suggest that magnesium increased whole blood glucose and magnesium levels during forced swimming; however, the effects of magnesium and swimming on GLUT-3 protein expression varied in different regions of the brain.
Relation:	international journal of sport and exercise science,, 2(1):19-26
Appears in Collections:	[Department of Psychology] Journal Article

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