Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect

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題名:	Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect
作者:	李家琳;Lee, Chia-Lin;王建旻;顏宏融;宋瑛琪;Song, Ying-Chyi;陳朝榮;Chen, Chao-Jung
貢獻者:	醫學暨健康學院醫學檢驗暨生物技術學系
關鍵詞:	Acanthaceae;IL-17A inhibition;Qing Dai;Strobilanthes cusia;indazole alkaloid;indigodole E.
日期:	2022-02-01
上傳時間:	2023-03-29 02:22:55 (UTC+0)
出版者:	亞洲大學
摘要:	One new indazole alkaloid, indigodole E (1), was isolated from a traditional Chinese medicine Qing Dai prepared from the aerial parts of Strobilanthes cusia. The structure of 1 was elucidated by NMR, MS, UV, and IR spectra as well as optical rotation. Additionally, compound 1 could obviously inhibit not only IL-17A protein production at concentrations from 1.25 to 2.5 μg/mL, but also IL-17 gene expression at concentrations from 5.0 to 10.0 μg/mL without cytotoxicity toward Th17 and Jukat cells, respectively. Overall, indazole analogue 1 could be the anti-IL 17 A contributor of Qing Dai in this investigation.
顯示於類別:	[生物科技學系] 期刊論文

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