Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/115428

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/115428

题名:	Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect
作者:	李家琳;Lee, Chia-Lin;王建旻;顏宏融;宋瑛琪;Song, Ying-Chyi;陳朝榮;Chen, Chao-Jung
贡献者:	醫學暨健康學院醫學檢驗暨生物技術學系
关键词:	Acanthaceae;IL-17A inhibition;Qing Dai;Strobilanthes cusia;indazole alkaloid;indigodole E.
日期:	2022-02-01
上传时间:	2023-03-29 02:22:55 (UTC+0)
出版者:	亞洲大學
摘要:	One new indazole alkaloid, indigodole E (1), was isolated from a traditional Chinese medicine Qing Dai prepared from the aerial parts of Strobilanthes cusia. The structure of 1 was elucidated by NMR, MS, UV, and IR spectra as well as optical rotation. Additionally, compound 1 could obviously inhibit not only IL-17A protein production at concentrations from 1.25 to 2.5 μg/mL, but also IL-17 gene expression at concentrations from 5.0 to 10.0 μg/mL without cytotoxicity toward Th17 and Jukat cells, respectively. Overall, indazole analogue 1 could be the anti-IL 17 A contributor of Qing Dai in this investigation.
显示于类别:	[生物科技學系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	55	检视/开启

在ASIAIR中所有的数据项都受到原著作权保护.