IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/115427

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/115427

Title:	IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis
Authors:	Wu, Tsung-Ju;Wu, Tsung-Ju;Sunny, Li-Yun;Chang, Sunny Li-Yun;Li, Chih-Yang;Lin, Chih-Yang;賴朝陽;Lai, Chao-Yang;He, Xiu-Yuan;He, Xiu-Yuan;Tsa, Chun-Hao;Tsai, Chun-Hao;Ko, Chih-Yuan;Ko, Chih-Yuan;Fong, Yi-Chin;Fong, Yi-Chin;Su, Chen-Ming;Su, Chen-Ming;Ta, Chih-Hsin;Tang, Chih-Hsin
Contributors:	醫學暨健康學院醫學檢驗暨生物技術學系
Keywords:	IL-17;VCAM-1;adhesion;monocytes;osteoarthritis.
Date:	2022-06-01
Issue Date:	2023-03-29 02:22:52 (UTC+0)
Publisher:	亞洲大學
Abstract:	Osteoarthritis (OA) is characterized by the infiltration and adhesion of monocytes into the inflamed joint synovium. Interleukin (IL)-17 is a critical inflammatory mediator that participates in the progression of OA, although the mechanisms linking IL-17 and monocyte infiltration are not well understood. Our analysis of synovial tissue samples retrieved from the Gene Expression Omnibus (GEO) dataset exhibited higher monocyte marker (CD11b) and vascular cell adhesion molecule 1 (VCAM-1) levels in OA samples than in normal, healthy samples. The stimulation of human OA synovial fibroblasts (OASFs) with IL-17 increased VCAM-1 production and subsequently enhanced monocyte adhesion. IL-17 affected VCAM-1-dependent monocyte adhesion by reducing miR-5701 expression through the protein kinase C (PKC)-α and c-Jun N-terminal kinase (JNK) signaling cascades. Our findings improve our understanding about the effect of IL-17 on OA progression and, in particular, VCAM-1 production and monocyte adhesion, which may help with the design of more effective OA treatments.
Appears in Collections:	[生物科技學系] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	104	View/Open

Loading...