IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis

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题名:	IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis
作者:	Wu, Tsung-Ju;Wu, Tsung-Ju;Sunny, Li-Yun;Chang, Sunny Li-Yun;Li, Chih-Yang;Lin, Chih-Yang;賴朝陽;Lai, Chao-Yang;He, Xiu-Yuan;He, Xiu-Yuan;Tsa, Chun-Hao;Tsai, Chun-Hao;Ko, Chih-Yuan;Ko, Chih-Yuan;Fong, Yi-Chin;Fong, Yi-Chin;Su, Chen-Ming;Su, Chen-Ming;Ta, Chih-Hsin;Tang, Chih-Hsin
贡献者:	醫學暨健康學院醫學檢驗暨生物技術學系
关键词:	IL-17;VCAM-1;adhesion;monocytes;osteoarthritis.
日期:	2022-06-01
上传时间:	2023-03-29 02:22:52 (UTC+0)
出版者:	亞洲大學
摘要:	Osteoarthritis (OA) is characterized by the infiltration and adhesion of monocytes into the inflamed joint synovium. Interleukin (IL)-17 is a critical inflammatory mediator that participates in the progression of OA, although the mechanisms linking IL-17 and monocyte infiltration are not well understood. Our analysis of synovial tissue samples retrieved from the Gene Expression Omnibus (GEO) dataset exhibited higher monocyte marker (CD11b) and vascular cell adhesion molecule 1 (VCAM-1) levels in OA samples than in normal, healthy samples. The stimulation of human OA synovial fibroblasts (OASFs) with IL-17 increased VCAM-1 production and subsequently enhanced monocyte adhesion. IL-17 affected VCAM-1-dependent monocyte adhesion by reducing miR-5701 expression through the protein kinase C (PKC)-α and c-Jun N-terminal kinase (JNK) signaling cascades. Our findings improve our understanding about the effect of IL-17 on OA progression and, in particular, VCAM-1 production and monocyte adhesion, which may help with the design of more effective OA treatments.
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