Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model

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Title:	Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model
Authors:	Sun, Jui-Ming;Sun, Jui-Ming;Agarw, Surbhi;Agarwal, Surbhi;Dnyan, Tushar;Desai, Tushar Dnyaneshwar;Ju, Da-Tong;Ju, Da-Tong;Ch, Yung-Ming;Chang, Yung-Ming;Shih-Chieh, L;Liao, Shih-Chieh;Tsung-Jung, H;Ho, Tsung-Jung;Yeh, Yu-Lan;Yeh, Yu-Lan;Kuo, Wei-Wen;Kuo, Wei-Wen;Lin, Yu-Jung;Lin, Yu-Jung;黃志揚;Huang, Chih-Yang
Contributors:	醫學暨健康學院醫學檢驗暨生物技術學系
Keywords:	Parkinson's disease;cryptotanshinone;neuroprotection;oxidative stress;paraquat. ? 2022 Wiley Periodicals LLC.
Date:	2022-09-01
Issue Date:	2023-03-29 02:05:34 (UTC+0)
Publisher:	亞洲大學
Abstract:	Parkinson's disease (PD) is a common neurodegenerative disorder associated with striatal dopaminergic neuronal loss in the Substantia nigra. Oxidative stress plays a significant role in several neurodegenerative diseases. Paraquat (PQ) is considered a potential neurotoxin that affects the brain leading to the death of dopaminergic neurons mimicking the PD phenotype. Various scientific reports have proven that cryptotanshinone possesses antioxidant and anti-inflammatory properties. We hypothesized that cryptotanshinone could extend its neuroprotective activity by exerting antioxidant effects. This study was designed to evaluate the effects of cryptotanshinone in both cellular and animal models of PQ-induced PD. Annexin V-PI double staining and immunoblotting were used to detect apoptosis and oxidative stress proteins, respectively. Reactive oxygen species kits were used to evaluate oxidative stress in cells. For in vivo studies, 18 B6 mice were divided into three groups. The rotarod data revealed the motor function and immunostaining showed the survival of TH+ neurons in SNpc region. Our study showed that cryptotanshinone attenuated paraquat-induced oxidative stress by upregulating anti-oxidant markers in vitro, and restored behavioral deficits and survival of dopaminergic neurons in vivo, demonstrating its therapeutic potential.
Appears in Collections:	[生物科技學系] 期刊論文

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