ASIA unversity:Item 310904400/115399
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 94286/110023 (86%)
造访人次 : 21710564      在线人数 : 448
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/115399


    题名: Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model
    作者: Sun, Jui-Ming;Sun, Jui-Ming;Agarw, Surbhi;Agarwal, Surbhi;Dnyan, Tushar;Desai, Tushar Dnyaneshwar;Ju, Da-Tong;Ju, Da-Tong;Ch, Yung-Ming;Chang, Yung-Ming;Shih-Chieh, L;Liao, Shih-Chieh;Tsung-Jung, H;Ho, Tsung-Jung;Yeh, Yu-Lan;Yeh, Yu-Lan;Kuo, Wei-Wen;Kuo, Wei-Wen;Lin, Yu-Jung;Lin, Yu-Jung;黃志揚;Huang, Chih-Yang
    贡献者: 醫學暨健康學院醫學檢驗暨生物技術學系
    关键词: Parkinson's disease;cryptotanshinone;neuroprotection;oxidative stress;paraquat. ? 2022 Wiley Periodicals LLC.
    日期: 2022-09-01
    上传时间: 2023-03-29 02:05:34 (UTC+0)
    出版者: 亞洲大學
    摘要: Parkinson's disease (PD) is a common neurodegenerative disorder associated with striatal dopaminergic neuronal loss in the Substantia nigra. Oxidative stress plays a significant role in several neurodegenerative diseases. Paraquat (PQ) is considered a potential neurotoxin that affects the brain leading to the death of dopaminergic neurons mimicking the PD phenotype. Various scientific reports have proven that cryptotanshinone possesses antioxidant and anti-inflammatory properties. We hypothesized that cryptotanshinone could extend its neuroprotective activity by exerting antioxidant effects. This study was designed to evaluate the effects of cryptotanshinone in both cellular and animal models of PQ-induced PD. Annexin V-PI double staining and immunoblotting were used to detect apoptosis and oxidative stress proteins, respectively. Reactive oxygen species kits were used to evaluate oxidative stress in cells. For in vivo studies, 18 B6 mice were divided into three groups. The rotarod data revealed the motor function and immunostaining showed the survival of TH+ neurons in SNpc region. Our study showed that cryptotanshinone attenuated paraquat-induced oxidative stress by upregulating anti-oxidant markers in vitro, and restored behavioral deficits and survival of dopaminergic neurons in vivo, demonstrating its therapeutic potential.
    显示于类别:[生物科技學系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML80检视/开启


    在ASIAIR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈