Contribution of 5-methyltetrahydrogolate-homocysteine methyltransferase reductase genotypes to colorectal cancer in Taiwan

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Title:	Contribution of 5-methyltetrahydrogolate-homocysteine methyltransferase reductase genotypes to colorectal cancer in Taiwan
Authors:	MH, Wu;MH, Wu;CH, Chen;CH, Chen;CP, Chen;CP, Chen;TL, Huang;TL, Huang;TC, Yueh;TC, Yueh;王智弘;Wang, Zhi-Hong;蒙美津;Mong, Mei-Chin;DT, Bau;DT, Bau
Contributors:	醫學暨健康學院食品營養與保健生技學系
Keywords:	Colorectal cancer, genotype, MMP-7, polymorphism, Taiwan
Date:	2022-05-01
Issue Date:	2023-03-29
Publisher:	亞洲大學
Abstract:	Background/Aim: Matrix metalloproteinases (MMPs) play important roles in inflammation and carcinogenesis, but the genotypic role of MMP-7 has never been investigated in colorectal cancer (CRC) among the Taiwanese. Therefore, in this study we aimed to evaluate the contribution of MMP-7 genotypes to the risk of CRC in Taiwan. Materials and Methods: In this case-control study, MMP-7 A-181G and C-153T promoter genotypes were determined and their association with CRC risk were investigated among 362 CRC patients and 362 age- and gender-matched healthy controls. In addition, the interaction of MMP-7 genotypes and personal behaviors were also examined. Results: The percentages of variant AG and GG for MMP-7 A-181G genotypes were 10.5% and 1.7% in the CRC group and 11.9% and 2.2% in the control group, respectively (p for trend=0.7145). The allelic frequency distribution analysis showed that the variant G allele of MMP-7 A-181G conferred a slight but non-significant decreased CRC susceptibility to the wild-type C allele (odds ratio (OR)=0.86, 95% confidence interval (CI)=0.64-1.31, p=0.37). Taiwanese all harbour the CC genotype at MMP-7 C-153T. As for the gene–lifestyle interaction, there were no obvious joint effects of MMP-7 A-181G genotype on the risk of CRC among ever smoker, alcohol drinker, non-smoker or non-drinker subgroups. No statistically significant correlation was observed between MMP-7 A-181G genotypic distributions and age, gender, tumor size, location or metastasis status. Conclusion: The genotypes of MMP-7 A-181G may play an indirect role in determining personal susceptibility to CRC and prognosis. The further genotyping work on MMP-7 and other genes (such as other MMPs, oncogenes and tumor suppression genes) on CRC susceptibility and prognosis, should be taken into consideration spontaneously in the precision medicine era.
Appears in Collections:	[食品營養與保健生技學系] 期刊論文

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