Contribution of 5-methyltetrahydrogolate-homocysteine methyltransferase reductase genotypes to colorectal cancer in Taiwan

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/115164

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题名:	Contribution of 5-methyltetrahydrogolate-homocysteine methyltransferase reductase genotypes to colorectal cancer in Taiwan
作者:	MH, Wu;MH, Wu;CH, Chen;CH, Chen;CP, Chen;CP, Chen;TL, Huang;TL, Huang;TC, Yueh;TC, Yueh;王智弘;Wang, Zhi-Hong;蒙美津;Mong, Mei-Chin;DT, Bau;DT, Bau
贡献者:	醫學暨健康學院食品營養與保健生技學系
关键词:	Colorectal cancer, genotype, MMP-7, polymorphism, Taiwan
日期:	2022-05-01
上传时间:	2023-03-29
出版者:	亞洲大學
摘要:	Background/Aim: Matrix metalloproteinases (MMPs) play important roles in inflammation and carcinogenesis, but the genotypic role of MMP-7 has never been investigated in colorectal cancer (CRC) among the Taiwanese. Therefore, in this study we aimed to evaluate the contribution of MMP-7 genotypes to the risk of CRC in Taiwan. Materials and Methods: In this case-control study, MMP-7 A-181G and C-153T promoter genotypes were determined and their association with CRC risk were investigated among 362 CRC patients and 362 age- and gender-matched healthy controls. In addition, the interaction of MMP-7 genotypes and personal behaviors were also examined. Results: The percentages of variant AG and GG for MMP-7 A-181G genotypes were 10.5% and 1.7% in the CRC group and 11.9% and 2.2% in the control group, respectively (p for trend=0.7145). The allelic frequency distribution analysis showed that the variant G allele of MMP-7 A-181G conferred a slight but non-significant decreased CRC susceptibility to the wild-type C allele (odds ratio (OR)=0.86, 95% confidence interval (CI)=0.64-1.31, p=0.37). Taiwanese all harbour the CC genotype at MMP-7 C-153T. As for the gene–lifestyle interaction, there were no obvious joint effects of MMP-7 A-181G genotype on the risk of CRC among ever smoker, alcohol drinker, non-smoker or non-drinker subgroups. No statistically significant correlation was observed between MMP-7 A-181G genotypic distributions and age, gender, tumor size, location or metastasis status. Conclusion: The genotypes of MMP-7 A-181G may play an indirect role in determining personal susceptibility to CRC and prognosis. The further genotyping work on MMP-7 and other genes (such as other MMPs, oncogenes and tumor suppression genes) on CRC susceptibility and prognosis, should be taken into consideration spontaneously in the precision medicine era.
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