Loading...
|
Please use this identifier to cite or link to this item:
http://asiair.asia.edu.tw/ir/handle/310904400/112843
|
| Title: | Ginsenoside Rg1 supplementation clears senescence-associated b-galactosidase in exercising human skeletal muscle |
| Authors: | Wu, Jinfu;Wu, Jinfu;Saov, Suchada;Saovieng, Suchada;Che, I-Shiung;Cheng, I-Shiung;Liu, Tiemin;Liu, Tiemin;Hon, Shangyu;Hong, Shangyu;Lin, Chang-Yu;Lin, Chang-Yu;Su, I-Chen;Su, I-Chen;黃志揚;Huang, Chih-Yang;Kuo, Chia-Hua;Kuo, Chia-Hua |
| Contributors: | 醫學檢驗暨生物技術學系 |
| Keywords: | Cellular senescence;Endurance;Ergogenic aid;Inflammation;Macrophage |
| Date: | 2019-11 |
| Issue Date: | 2020-08-31 07:41:13 (UTC+0) |
| Publisher: | 亞洲大學 |
| Abstract: | Background: Ginsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-bgal) in cultured cells. It remains unknown whether Rg1 can influence SA-b-gal in exercising human
skeletal muscle.
Methods: To examine SA-b-gal change, 12 young men (age 21 0.2 years) were enrolled in a randomized
double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg)
supplementations 1 h prior to a high-intensity cycling (70% VO2max). Muscle samples were collected by
multiple biopsies before and after cycling exercise (0 h and 3 h). To avoid potential effect of muscle
biopsy on performance assessment, cycling time to exhaustion test (80% VO2max) was conducted on
another 12 participants (age 23 0.5 years) with the same experimental design.
Results: No changes of SA-b-gal were observed after cycling in the PLA trial. On the contrary, nine of the 12
participants showed complete elimination of SA-b-gal in exercised muscle after cycling in the Rg1 trial
(p < 0.05). Increases in apoptotic DNA fragmentation (PLA: þ87% vs. Rg1: þ133%, p < 0.05) and CD68þ
(PLA:þ78% vs. Rg1:þ121%, p ¼ 0.17) occurred immediately after cycling in both trials. During the 3-h recovery,
reverses in apoptotic nuclei content (PLA:þ5% vs. Rg1:32%, p < 0.01) and increases in inducible nitrate oxide
synthase and interleukin 6 mRNA levels of exercised muscle were observed only in the Rg1 trial (p < 0.01).
Conclusion: Rg1 supplementation effectively eliminates senescent cells in exercising human skeletal
muscle and improves high-intensity endurance performance. |
| Relation: | Journal of Ginseng Research |
| Appears in Collections: | [醫學檢驗暨生物技術學系] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| index.html | | 0Kb | HTML | 277 | View/Open |
|
All items in ASIAIR are protected by copyright, with all rights reserved.
|
