Ginsenoside Rg1 supplementation clears senescence-associated b-galactosidase in exercising human skeletal muscle

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题名:	Ginsenoside Rg1 supplementation clears senescence-associated b-galactosidase in exercising human skeletal muscle
作者:	Wu, Jinfu;Wu, Jinfu;Saov, Suchada;Saovieng, Suchada;Che, I-Shiung;Cheng, I-Shiung;Liu, Tiemin;Liu, Tiemin;Hon, Shangyu;Hong, Shangyu;Lin, Chang-Yu;Lin, Chang-Yu;Su, I-Chen;Su, I-Chen;黃志揚;Huang, Chih-Yang;Kuo, Chia-Hua;Kuo, Chia-Hua
贡献者:	醫學檢驗暨生物技術學系
关键词:	Cellular senescence;Endurance;Ergogenic aid;Inflammation;Macrophage
日期:	2019-11
上传时间:	2020-08-31 07:41:13 (UTC+0)
出版者:	亞洲大學
摘要:	Background: Ginsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-bgal) in cultured cells. It remains unknown whether Rg1 can influence SA-b-gal in exercising human skeletal muscle. Methods: To examine SA-b-gal change, 12 young men (age 21 0.2 years) were enrolled in a randomized double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg) supplementations 1 h prior to a high-intensity cycling (70% VO2max). Muscle samples were collected by multiple biopsies before and after cycling exercise (0 h and 3 h). To avoid potential effect of muscle biopsy on performance assessment, cycling time to exhaustion test (80% VO2max) was conducted on another 12 participants (age 23 0.5 years) with the same experimental design. Results: No changes of SA-b-gal were observed after cycling in the PLA trial. On the contrary, nine of the 12 participants showed complete elimination of SA-b-gal in exercised muscle after cycling in the Rg1 trial (p < 0.05). Increases in apoptotic DNA fragmentation (PLA: þ87% vs. Rg1: þ133%, p < 0.05) and CD68þ (PLA:þ78% vs. Rg1:þ121%, p ¼ 0.17) occurred immediately after cycling in both trials. During the 3-h recovery, reverses in apoptotic nuclei content (PLA:þ5% vs. Rg1:32%, p < 0.01) and increases in inducible nitrate oxide synthase and interleukin 6 mRNA levels of exercised muscle were observed only in the Rg1 trial (p < 0.01). Conclusion: Rg1 supplementation effectively eliminates senescent cells in exercising human skeletal muscle and improves high-intensity endurance performance.
關聯:	Journal of Ginseng Research
显示于类别:	[醫學檢驗暨生物技術學系] 期刊論文

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