A theranostic approach to breast cancer by a quantum dots- and magnetic nanoparticles-conjugated peptide

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/112053

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題名:	A theranostic approach to breast cancer by a quantum dots- and magnetic nanoparticles-conjugated peptide
作者:	Chih-Hsiang;Chang, Chih-Hsiang;Tsai, I-Chi;Tsai, I-Chi;Ch, Chung-Jen;Chiang, Chung-Jen;Cha, Yun-Peng;Chao, Yun-Peng
貢獻者:	食品營養與保健生技學系
日期:	2019-02
上傳時間:	2019-09-18 02:48:06 (UTC+0)
摘要:	The heterogeneous nature of cancers renders the efficacy of the therapeutic treatment diversified. To address this issue, a theranostic approach was proposed by development of a hybrid peptide for simultaneous diagnosis and therapy of cancer cells. Peptide A was composed of the biotinylation site (BS), the HER2/neu-binding motif, and the dockerin domain (Doc). Peptide B was designed with BS and the cohesin domain (Coh). Individually expressed in Escherichia coli, peptide A and peptide B were isolated and then functionalized by conjugation with quantum dots (QDs)-streptavidin and magnetic nanoparticles (MNPs)-streptavidin, respectively. A hybrid peptide was assembled by coupling of the QDs-peptide with the MNPs-conjugated peptide via the Doc-Coh interaction. By administration of the hybrid peptide, HER2/neu-positive breast cancer cells were detected and destroyed as a result of the QDs-emitted fluorescence and the MNPs-mediated hyperthermia.
關聯:	Journal of the Taiwan Institute of Chemical Engineers
顯示於類別:	[食品營養與保健生技學系] 期刊論文

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