A theranostic approach to breast cancer by a quantum dots- and magnetic nanoparticles-conjugated peptide

ASIAIR > College of Medical and Health Science > Department of Food Nutrition and Healthy Biotechnology > Journal Article > Item 310904400/112053

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112053

Title:	A theranostic approach to breast cancer by a quantum dots- and magnetic nanoparticles-conjugated peptide
Authors:	Chih-Hsiang;Chang, Chih-Hsiang;Tsai, I-Chi;Tsai, I-Chi;Ch, Chung-Jen;Chiang, Chung-Jen;Cha, Yun-Peng;Chao, Yun-Peng
Contributors:	食品營養與保健生技學系
Date:	2019-02
Issue Date:	2019-09-18 02:48:06 (UTC+0)
Abstract:	The heterogeneous nature of cancers renders the efficacy of the therapeutic treatment diversified. To address this issue, a theranostic approach was proposed by development of a hybrid peptide for simultaneous diagnosis and therapy of cancer cells. Peptide A was composed of the biotinylation site (BS), the HER2/neu-binding motif, and the dockerin domain (Doc). Peptide B was designed with BS and the cohesin domain (Coh). Individually expressed in Escherichia coli, peptide A and peptide B were isolated and then functionalized by conjugation with quantum dots (QDs)-streptavidin and magnetic nanoparticles (MNPs)-streptavidin, respectively. A hybrid peptide was assembled by coupling of the QDs-peptide with the MNPs-conjugated peptide via the Doc-Coh interaction. By administration of the hybrid peptide, HER2/neu-positive breast cancer cells were detected and destroyed as a result of the QDs-emitted fluorescence and the MNPs-mediated hyperthermia.
Relation:	Journal of the Taiwan Institute of Chemical Engineers
Appears in Collections:	[Department of Food Nutrition and Healthy Biotechnology] Journal Article

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	354	View/Open

View Licence