A study to evaluate the potential of an in silico approach for predicting dipeptidyl peptidase-IV inhibitory activity in vitro of protein hydrolysates

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/108400

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题名:	A study to evaluate the potential of an in silico approach for predicting dipeptidyl peptidase-IV inhibitory activity in vitro of protein hydrolysates
作者:	王子源;Tzu-Yuan Wang;謝承紘;Cheng-Hong Hsieh;洪娟娟;Hung Chuan-Chuan;饒家麟;Chia-Ling Jao;林佩儀;Pei-Yi Lin;謝宥諒;You-Liang Hsieh;徐國強;Hsu Kuo-Chiang
贡献者:	保健營養生技學系
日期:	2017-11
上传时间:	2017-12-08 06:10:42 (UTC+0)
摘要:	A total of 294 edible protein sequences and 5 commercial proteases listed in the BIOPEP database were analyzed in silico. The frequency (A), a parameter in silico described previously, was examined further to calculating the ratio of truncated peptides with Xaa-proline and/or Xaa-alanine to all peptide fragments in a protein hydrolyzed with a protease, using the BIOPEP database. Then the in vitro DPP-IV inhibitory activity was determined using the same 15 protein and protease combinations to evaluate their relationship. The result shows that A values considering the number of Xaa-proline + Xaa-alanine exhibited a strong correlation with in vitro DPP-IV inhibition rates by Pearson’s correlation analysis (r = 0.6993; P < 0.05). Therefore, the in silico approach is effective to predict DPP-IV inhibitory activities in vitro of protein hydrolysates.
關聯:	FOOD CHEMISTRY
显示于类别:	[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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