A study to evaluate the potential of an in silico approach for predicting dipeptidyl peptidase-IV inhibitory activity in vitro of protein hydrolysates

ASIAIR > College of Medical and Health Science > Department of Food Nutrition and Healthy Biotechnology > Journal Article > Item 310904400/108400

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/108400

Title:	A study to evaluate the potential of an in silico approach for predicting dipeptidyl peptidase-IV inhibitory activity in vitro of protein hydrolysates
Authors:	王子源;Tzu-Yuan Wang;謝承紘;Cheng-Hong Hsieh;洪娟娟;Hung Chuan-Chuan;饒家麟;Chia-Ling Jao;林佩儀;Pei-Yi Lin;謝宥諒;You-Liang Hsieh;徐國強;Hsu Kuo-Chiang
Contributors:	保健營養生技學系
Date:	2017-11
Issue Date:	2017-12-08 06:10:42 (UTC+0)
Abstract:	A total of 294 edible protein sequences and 5 commercial proteases listed in the BIOPEP database were analyzed in silico. The frequency (A), a parameter in silico described previously, was examined further to calculating the ratio of truncated peptides with Xaa-proline and/or Xaa-alanine to all peptide fragments in a protein hydrolyzed with a protease, using the BIOPEP database. Then the in vitro DPP-IV inhibitory activity was determined using the same 15 protein and protease combinations to evaluate their relationship. The result shows that A values considering the number of Xaa-proline + Xaa-alanine exhibited a strong correlation with in vitro DPP-IV inhibition rates by Pearson’s correlation analysis (r = 0.6993; P < 0.05). Therefore, the in silico approach is effective to predict DPP-IV inhibitory activities in vitro of protein hydrolysates.
Relation:	FOOD CHEMISTRY
Appears in Collections:	[Department of Food Nutrition and Healthy Biotechnology] Journal Article

Files in This Item:

File	Size	Format
index.html	0Kb	HTML	478	View/Open