Development of standardized methodology for identifying toxins in clinical samples and fish species associated with tetrodotoxin-borne poisoning incidents

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Title:	Development of standardized methodology for identifying toxins in clinical samples and fish species associated with tetrodotoxin-borne poisoning incidents
Authors:	謝承紘(Cheng-Hong Hsieh)
Contributors:	保健營養生技學系
Date:	2016
Issue Date:	2016-08-08 03:27:17 (UTC+0)
Abstract:	Tetrodotoxin (TTX) is a naturally occurring toxin in food, especially in puffer fish. TTX poisoning is observed frequently in South East Asian regions. In TTX-derived food poisoning outbreaks, the amount of TTX recovered from suspicious fish samples or leftovers, and residual levels from biological fluids of victims are typically trace. However, liquid chromatographyâmass spectrometry and liquid chromatographyâtandem mass spectrometry methods have been demonstrated to qualitatively and quantitatively determine TTX in clinical samples from victims. Identification and validation of the TTX-originating seafood species responsible for a food poisoning incident is needed. A polymerase chain reaction-based method on mitochondrial DNA analysis is useful for identification of fish species. This review aims to collect pertinent information available on TTX-borne food poisoning incidents with a special emphasis on the analytical methods employed for TTX detection in clinical laboratories as well as for the identification of TTX-bearing species.
Relation:	JOURNAL OF FOOD AND DRUG ANALYSIS
Appears in Collections:	[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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