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    題名: Phytochemicals from Tradescantia albiflora Kunth extracts reduce serum uric acid levels in oxonate-induced mice
    作者: Wang), Wen-Ling Wan(Wen-Ling;Sheu), Shi-Yuan She(Shi-Yuan;Huang), Wen-Dar Huan(Wen-Dar;Chuang), Ya-Ling Chua(Ya-Ling;Tseng), Han-Chun Tse(Han-Chun;Hwang), Tzann-Shun H(Tzann-Shun;Fu), Yuan-Tsung F(Yuan-Tsung;Kuo), Yueh-Hsiung(Yueh-Hsiung;Yao)*, 姚俊旭(Chun-Hsu;Kuo), Tzong-Fu Kuo(Tzong-Fu
    貢獻者: 生物資訊與醫學工程學系
    日期: 2016-08
    上傳時間: 2016-08-08 03:15:53 (UTC+0)
    摘要: Background:

    Tradescantia albiflora  (TA) Kunth  (Commelinaceae) has
    been used for treating gout and hyperuricemia as folklore remedies in
    Taiwan. Therefore, it is worthwhile to study the effect of TA extracts on
    lowering uric acid activity. The hypouricemic effects of TA extracts on
    potassium oxonate  (PO)‑induced acute hyperuricemia were investigated
    for the first time.

    Materials and Methods:

    All treatments at the same
    volume  (1 ml) were orally administered to the abdominal cavity of
    PO‑induced hyperuricemic rats. One milliliter of TA extract in n-hexane
    (HE), ethyl acetate (EA), n-butanol (BuOH), and water fractions has 0.28,
    0.21, 0.28, and 1.03 mg TA, respectively; and the plasma uric acid  (PUA)
    level was measured for a consecutive 4 h after administration.

    Results:

    All four fractions’ extracts derived from TA were observed to significantly
    reduce PUA compared with the PO group. The EA‑soluble fraction (TA‑EA)
    exhibited the best xanthine oxidase  (XO) inhibitory activity. Following
    column chromatography, 12 phytochemicals were isolated and identified
    from the EA fraction. The IC50 values of isolated phytochemicals indicated
    that bracteanolide A  (AR11) showed the remarkable XO inhibitory
    effect (IC50 value of 76.4 µg/ml). These findings showed that the in vivo
    hypouricemic effect in hyperuricemic rats was consistent with in vitro XO
    inhibitory activity, indicating that TA extracts and derived phytochemicals
    could be potential candidates as hypouricemic agents.
    關聯: Pharmacognosy Magazine
    顯示於類別:[生物資訊與醫學工程學系 ] 期刊論文

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