The pig as an experimental model for mid-dermal burns research

ASIA unversity > 資訊學院 > 生物資訊與醫學工程學系 > 期刊論文 > Item 310904400/87049

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/87049

Title:	The pig as an experimental model for mid-dermal burns research
Authors:	Shi-Yuan Sheu;Wen-Ling Wang;Yuan-Tsung Fu;Sheng-Chuan Linf, Yi-Chih Lei;Jeng-Hao Liao;Nou-Ying Tang;Tzong-Fu Kuo
Contributors:	生物與醫學資訊學系
Keywords:	Burns;Burns depth;Histology;Macroscopy;Porcine burn model;Wound healing Burns;Porcine burn model;Burns depth;Wound healing;Macroscopy;Histology
Date:	2014-05
Issue Date:	2014-11-13 07:02:34 (UTC+0)
Abstract:	This was a novel, prospective and interventional animal study designed to develop and evaluate a new infliction device for the experimental burn model. Four paired sets of contact burns measuring 36mm diameter were inflicted on the dorsum of an anesthetized pig using a stainless steel round bar heated up to 80-110°C. The bar was applied using a push-pull force gauge designed to control 1kgf mechanical force applied to the skin for a period of 20s. The left dorsum was used for macroscopic observation and the right dorsum was used for histopathological evaluation. A total of eight burns were covered with moist saline dressings and given daily treatments of xylocaine (lidocaine HCl) gel. This procedure was followed for a period of 24 days. Full-thickness biopsies were obtained for histologic analysis to determine the extent of injury. Statistical analysis showed a high correlation between the exposure temperature and histopathological assessment. The results found the depth of injury to the collagen (Seg1) correlated with the temperature (Ti) at which the burns was inflicted, Seg1=0.038Ti-2.57 (r=0.973, P<0.05). Also, the histological studies show a high correlation between the depth of collagen denaturation in wounds and the exposure temperature, Seg1=0.0268Ti-0.165 (r=0.991, P<0.05). This model is useful to assess more closely the therapeutic agents used for wound healing in experimental burn wounds. Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.
Relation:	BURNS;40(8):1679-88.
Appears in Collections:	[生物資訊與醫學工程學系 ] 期刊論文

Files in This Item:

File	Size	Format
index.html	0Kb	HTML	551	View/Open

Loading...