Leptin Induces Oncostatin M Production in Osteoblasts by Downregulating miR-93 through the Akt Signaling Pathway.

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/86919

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题名:	Leptin Induces Oncostatin M Production in Osteoblasts by Downregulating miR-93 through the Akt Signaling Pathway.
作者:	Yan, Wei-Hung;Yang, Wei-Hung;Tsa, Chun-Hao;Tsai, Chun-Hao;Fong, Yi-Chin;Fong, Yi-Chin;黃元勵;HUANG, YUAN-LI;Wa, Shoou-Jyi;Wang, Shoou-Jyi;Cha, Yung-Sen;Chang, Yung-Sen;湯智昕;Chih-Hsin, Tang;*
贡献者:	生物科技學系
日期:	2014-09
上传时间:	2014-11-07 06:50:31 (UTC+0)
摘要:	Inflammatory response and articular destruction are common symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA). Leptin, an adipocyte-secreted hormone that centrally regulates weight control, may exert proinflammatory effects in the joint, depending on the immune response. Yet, the mechanism of leptin interacting with the arthritic inflammatory response is unclear. This study finds that leptin increased expression of oncostatin M (OSM) in human osteoblasts in a concentration- and time-dependent manner. In addition, OBRl, but not OBRs receptor antisense oligonucleotide, abolished the leptin-mediated increase of OSM expression. On the other hand, leptin inhibited miR-93 expression; an miR-93 mimic reversed leptin-increased OSM expression. Stimulation of osteoblasts with leptin promoted Akt phosphorylation, while pretreatment of cells with Akt inhibitor or siRNA reversed leptin-inhibited miR-93 expression. Our results showed that leptin heightened OSM expression by downregulating miR-93 through the Akt signaling pathway in osteoblasts, suggesting leptin as a novel target in arthritis treatment.
關聯:	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES;15(9):15778-90.
显示于类别:	[生物科技學系] 期刊論文

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