Briaexcavatins V-Z, discovery of new briaranes from a cultured octocoral briareum excavatum

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Title:	Briaexcavatins V-Z, discovery of new briaranes from a cultured octocoral briareum excavatum
Authors:	Sung, Ping-Jyun;Lin, Mei-Ru;Chiang, Michael Y.;Hwang, Tsong-Long
Contributors:	Department of Bioinformatics
Keywords:	Oxygen;X ray diffraction;Epoxy group;Human neutrophil;Human neutrophil elastase;Inhibitory effect;NMR chemical shifts;Single crystal x-ray diffraction;Spectroscopic method;Superoxide anions
Date:	2009
Issue Date:	2010-04-07 13:21:14 (UTC+0)
Publisher:	Asia University
Abstract:	Five new briarane derivatives, briaexcavatins V-Z(1-5), have been isolated from a cultured octocoral Briareum excavatum. The structures of compounds 1-5 were established by spectroscopic methods. Single-crystal X-ray diffraction data for 2 confirmed the structure. Briarane 4 possesses an unprecedented 8, 9-epoxy moiety. The relationships between <sup>13</sup>C NMR chemical shifts and the conformations of briaranes possessing an 11, 12-epoxy group are described. Briaranes 1, 3, and 4 have displayed weak inhibitory effects on superoxide anion generation by human neutrophils. Briarane 1 was found to show mild inhibitory effects on human neutrophil elastase release and 5 exhibited mild activity to enhance human neutrophil elastase release. © 2009 The Chemical Society of Japan.
Relation:	Bulletin of the Chemical Society of Japan 82(8):987-996
Appears in Collections:	[生物資訊與醫學工程學系 ] 期刊論文

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