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http://asiair.asia.edu.tw/ir/handle/310904400/8368
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| Title: | G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan |
| Authors: | Lin, YJ (Lin, Ying-Ju);Wan, L (Wan, Lei);Sheu, JJC (Sheu, Jim Jinn-Chyuan);Huang, CM (Huang, Chung-Ming);Lin, CW (Lin, Cheng-Wen);Lan, YC (Lan, Yu-Ching);Lai, CH (Lai, Chih-Ho);Hung, CH (Hung, Chien-Hui);Tsai, YH (Tsai, Yuhsin);Tsai, CH (Tsai, Chang-Hai);Lin, WY (Lin, Wei-Yong);Liu, HP (Liu, Hsin-Ping);Lin, TH (Lin, Ting-Hsu);Huang, YM (Huang, Yu-Min);Tsai, FJ (Tsai, Fuu-Jen) |
| Contributors: | Department of Biotechnology |
| Keywords: | systemic lupus;erythematosus;interleukin-2;single nucleotide;polymorphism;IL-2 GENE POLYMORPHISMS;T-CELLS;RHEUMATOID-ARTHRITIS;SIGNAL-TRANSDUCTION;CYTOKINE PRODUCTION;MULTIPLE-SCLEROSIS;DISEASE;ASSOCIATION;LYMPHOCYTES;RECEPTOR |
| Date: | 2009 |
| Issue Date: | 2010-03-26 02:30:07 (UTC+0) |
| Publisher: | Asia University |
| Abstract: | Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10− 14; OR = 3.94; 95% CI = 2.74–5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01–17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19–0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. |
| Relation: | CLINICAL IMMUNOLOGY, 129 (1): 36-39 OCT 2008 |
| Appears in Collections: | [生物科技學系] 期刊論文
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| 264.docx | | 0Kb | Unknown | 584 | View/Open | | 310904400-8368 .doc | | 42Kb | Microsoft Word | 379 | View/Open |
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