PKC and MEK pathways inhibit caspase-9/-3-mediated cytotoxicity in differentiated cells

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/8331

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题名:	PKC and MEK pathways inhibit caspase-9/-3-mediated cytotoxicity in differentiated cells
作者:	Yiang, GT (Yiang, Giou-Teng);Yu, YL (Yu, Yung-Luen);Hu, SC (Hu, Sheng-Chuan);Chen, MHC (Chen, Mark Hung-Chih);Wang, JH (Wang, Jaang-Hun);Wei, CW (Wei, Chyou-Wei)
贡献者:	Department of Biotechnology
关键词:	caspases;PKC;MEK;differentiation;RANA-CATESBEIANA RIBONUCLEASE;PROTEIN-KINASE-C;INDUCED APOPTOSIS;RETINOIC ACID;IFN-GAMMA;T-CELLS;ACTIVATION;HL-60;INDUCTION;DEATH
日期:	2008-03
上传时间:	2010-03-26 02:29:52 (UTC+0)
出版者:	Asia University
摘要:	Many studies have indicated that differentiated cells inhibit drug-induced cytotoxicity but undifferentiated cells do not, though the mechanisms are unclear. Currently, HL-60 cells are induced to differentiate into macrophage-like cells with Phor-bol-12-myristate-13-acetate (TPA) treatment (TPA-differentiated cells). Our study shows that caspase-9/-3-mediated cytotoxicity can be induced in undifferentiated HL-60 cells but not in TPA-differentiated HL-60 cells. However, caspase-9/-3-mediated cytotoxicity can be induced in TPA-differentiated cells if they are pretreated with a protein kinase C (PKC) or a mitogen activated protein kinase (MEK) inhibitor. Taken together, this study demonstrates that TPA-differentiated HL-60 cells inhibit caspases-9/-3-mediated cytotoxicity through the PKC and MEK signaling pathways. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
關聯:	FEBS LETTERS, 582 (6): 881-885
显示于类别:	[生物科技學系] 期刊論文

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