Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/8329

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Title:	Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse
Authors:	Chen, HY (Chen, Huey-Yi);Wan, L (Wan, Lei);Chung, YW (Chung, Ya-Wen);Chen, WC (Chen, Wei-Chi);Tsai, FJ (Tsai, Fuu-Jen);Tsai, CH (Tsai, Chang-Hai)
Contributors:	Department of Biotechnology
Keywords:	pelvic organ prolapse;estrogen receptor beta gene polymorphism;haplotype;URINARY-INCONTINENCE;CESAREAN-SECTION;FLOOR DISORDERS;LIGAMENTS
Date:	2008-05
Issue Date:	2010-03-26 02:29:51 (UTC+0)
Publisher:	Asia University
Abstract:	Objective: Estrogen and estrogen receptors are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether estrogen receptor beta (ER beta) gene polymorphisms were associated with POP by conducting a case-control association study in 69 women with POP and 141 women without POP. Study design: Genotypes of the ER beta gene polymorphisms (rs2987983, rs1271572, rs944459, rs1256049, and rs1255998) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. Haplotyping analysis was used to determine the relationship among five polymorphisms in the ER beta gene and POP. Results: There was no significant difference between women with and those without POP in the distribution of any of the genotypes evaluated. In haplotype frequency estimation analysis, haplotype CGCGC was more prevalent in women with POP (16.7%) than in women without POP (8.9%) (p = 0.011). Using multivariable logistic regression, age, parity and haplotype CGCGC were significantly associated with POP. Conclusion: Although the sample size of women with POP studied is small, the present study shows that ER beta gene haplotype may be associated with POP. (c) 2008 Published by Elsevier Ireland Ltd.
Relation:	EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 138 (1): 105-109
Appears in Collections:	[生物科技學系] 期刊論文

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