Curcumin Inhibits Human Lung Large Cell Carcinoma Cancer Tumour Growth in a Murine Xenograft Model

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/8230

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8230

Title:	Curcumin Inhibits Human Lung Large Cell Carcinoma Cancer Tumour Growth in a Murine Xenograft Model
Authors:	Su, CC (Su, Chin-Cheng);Yang, JS (Yang, Jai-Sing);Lu, CC (Lu, Chi-Cheng);Chiang, JH (Chiang, Jo-Hua);Wu, CL (Wu, Chang-Lin);Lin, JJ (Lin, Jen-Jyh);Lai, KC (Lai, Kuang-Chi);Hsia, TC (Hsia, Te-Chun);Lu, HF (Lu, Hsu-Feng);Fan, MJ (Fan, Ming-Jen);Chung, JG (Chung, Jing-Gung)
Contributors:	Department of Biotechnology
Keywords:	curcumin;human lung NCI-H460 cancer cells;xenograft transplantation;in vivo
Date:	2010-02
Issue Date:	2010-03-26 02:29:12 (UTC+0)
Publisher:	Asia University
Abstract:	Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once ever), 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg an 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo. Copyright (C) 2010 John Wiley & Sons, Ltd.
Relation:	PHYTOTHERAPY RESEARCH 24 (2): 189-192
Appears in Collections:	[生物科技學系] 期刊論文

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